![]() ![]() ![]() The distribution of linezolid is approximately equivalent to total body water, and there is low protein binding (31%) to serum albumin. Food slightly decreases the rate, but not the extent, of absorption. Maximum plasma linezolid concentrations are usually achieved between 1 and 2 hours after oral administration. Linezolid is fully bioavailable following oral administration when compared with intravenous administration. The drug has substantial antimicrobial activity against Gram-positive organisms such as streptococci, staphylococci and enterococci, including species resistant to conventional antibacterial treatment. Linezolid is the first antibacterial to be approved from the oxazolidinone class. ![]()
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